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Studies show that food decreases the rate and extent of absorption (also known as bioavailability). If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal Drug Interactions. Lisinopril can increase blood potassium levels. After the very first dose, you can take lisinopril at any time of day. You can take lisinopril with or without food. It is best to swallow the tablet with a drink of water. Moderate Food Interaction It is recommended that if you are taking lisinopril you should be advised to avoid moderately high or high potassium dietary intake. Those without any other health conditions, and who currently maintain a healthy weight, often need no dietary restrictions. Take with food or on an empty stomach does not affect lisinopril. More About Lisinopril Lisinopril Drug Basics and Uses. Your doctor may adjust your dose as needed. 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